Samir Zard provides a description of radical reactions and their applications in organic synthesis. This book shows that an with an elementary knowledge of kinetic and some common sense, it is possible to harness radicals into a tremendously powerful tool for solving synthetic problems. Carbohydrates offer a ready source of enantiomerically pure starting materials. They have been used for the imaginative synthesis of a wide range of compounds, and have been found to be effective chiral auxiliaries which enable the introduction of a range of functionalities in a highly enantioselective manner.
In a subject dominated by volumes at research and professional level, this book provides a broad understanding of the use of carbohydrates in organic synthesis, at postgraduate student level. Emphasis is placed on retrosynthetic analysis, with discussion of why a particular synthetic route has been chosen, and mechanistic explanations are provided for key and novel reactions.
Wherever possible, the authors highlight points of general significance to organic synthesis. Selected experimental conditions and reaction details are incorporated to ensure that information can be utilised in research. The book is extensively referenced and so provides a convenient point of entry to the primary literature.
Compatible with any devices. Selectivity is an important part of organic synthesis. The whole basis of organic chemistry, and especially organic synthesis, depends upon the selectivity which can be achieved in organic reactions. This concise textbook describes the strategies which can be adopted to improve selectivity, and the reactions which have been specially designed to afford high selectivity.
The book illustrates the range of processes to which these principles can be applied and the high degree of selectivity which can be achieved. Selectivity in Organic Synthesis provides a solid introduction to this subject, focusing on the key areas and applications. Suitable for organic chemistry students taking a course on organic synthesis or asymmetric synthesis in the 3rd or final year of an undergraduate chemistry course or in the first year of a postgraduate course.
This book is a useful field guide for the practicing organic chemist and a rich introduction for the student. Functional group transformations, new catalysts, and improved enantioselective methods are included. Many current total syntheses are also discussed in detail.
The application of silicon reagents in organic synthesis has grown at an increasingly rapid rate over the last twenty years. This has been the result of truly international interest. Signifi cant contributions have been made by Japanese, Russian, Ger man, French, English, American, Swiss and Canadian as well as by chemists from many other countries.
This monograph attempts to comprehensively cover this field. Some seventeen hundred articles reporting contributions by over eighteen hundred scientists are summarized. Nevertheless, I have no doubt that interesting and important work has been left out. I welcome comments about such results which should be in cluded in any future editions of this monograph. I would like to thank Robert Damrauer who first stimulated my interest in organosilicon chemistry.
In addition, I thank a number of chemists who have shared my enthusiasm for silicon chemistry over the years: A Chihi, M. Childs, R. A Felix, H. Firgo, T. Gu, T. Llto, LN. Jung, K. Koenig, H. Okinoshima, M.
Radcliffe, B. L Rosen, H. Soy sa, K. Steele, R. Swaim, D. Tzeng, P. Valkovich, AK. Will ard, S. Wunderly, and present members of my research group. Author : Philip L. Charette,Tomislav Rovis,Jeffrey W. Author : Reinhart Keese,Martin P. Author : Michael C. Author : Patrick H. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents.
Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type.
For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents.
Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists.
The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry. This handbook offers authoratative information on how noncovalent and covalent templates can be effectively applied to control reaction rates as well as regio- and stereoselectivity. From the concepts of template control such as molecular imprinting, self-replication, and reversible tether-directed remote functionalization, the reader is led to template-based ring-closing reactions, oligomerizations, and multiple functionalizations and their application in the synthesis of supramolecular scaffolds and natural products.
The editors and authors J. Stoddart, G. Wulf, D. Lynn, R. Diederich, just to name a few , all internationally recognized experts in their area, succeeded in presenting the manifold aspects of template-controlled synthesis in a didactic way, making this methodology accessible to a broad readership of organic synthetic chemists.
Well-selected, reliable key experimental protocols and an up-to-date reference list underline the practical approach of this valuable handbook.
Being the first book of its kind, it will serve as a pacemaker and stimulate future research. Phase transfer catalysis is a solution to numerous cost and yield problems encountered regularly in industrial laboratories. In fact, much of the early work in this area was conducted by industrial chemists although the work was not labelled phase transfer catalysis at the time.
We certainly do not intend to minimize the contributions of academic chemists to this field, but it is an unalterable fact that much of the early understanding and many of the early advances came from industrial laboratories.
A special tribute is due to Dr. Charles Starks of the Continental Oil Company. By the mid sixties, Starks had formulated the principles of phase transfer catalysis and had applied for patents on many reactions that others were later to examine in somewhat greater detail.
His mechanistic model of phase transfer catalysis still stands up well today and is a model for much of the thinking in this area. It is fitting that Starks suggested the name "phase transfer catalysis" by which the whole field is now known.
We wish to thank a number of people who have aided us in many ways in the preparation of this volume. We very much appreciate the helpful discussions and insights provided by Drs. This makes the articles very focused on the needs of readers wanting information on specific syntheses of specific heteroarenes.
The Handbook is a part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis.
The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic Synthesis series compiles articles taken from the e-eros database, on reagents for use in radical and radical chemistry, to help the chemist in the lab choose the right reagents. Reflecting the enormous growth of radical chemistry over the past ten years, this is an essential guide for all synthetic chemists.
An introductory section covers practical questions on how to run a photochemical reaction, while all classes of the most important photocatalytic reactions are also included.
Perfect for organic synthetic chemists in academia and industry.
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